NTRC delivers Precision Medicine services for drug discovery. We are a contract research organisation for drug discovery. This category relates to the services portfolio. Most services are related to the development of anti cancer drugs and cancer immunotherapy therapeutics. Our most important services are in the field of cellular assays. One of the service offerings relates to proliferation of cancer cell lines in response to anti cancer therapeutics. A panel of 102 cancer cell lines is incubated with the drug for 3 or 5 days. After incubation the viability of the cells is measured. We measure the viability at 9 concentration points in duplicate. By doing so, we can generate dose response curves. The results are highly reproducible. Precision Medicine Services for drug discovery imply that we provide insight into the mechanism of the tested therapeutics. This is delivered by bioinformatics analysis.
Case study: Phosphorylation status determines kinase inhibitor binding
April 28, 2021: A new case [...]